PEAR? Where staff participated in trials, rather than doing double blind experiments? Whose results could not be reproduced by independent research groups? Who were found to employ p-hacking and data cherry picking?
You might as well argue that simulating a human mind is not possible because it wouldn’t have a zodiac sign.
Yes the connectome is kind of critical. But other than that, sub threshold oscillations can and are being modeled. It also does not really matter that we are digitizing here. Fluid dynamics are continuous and we can still study, model and predict it using finite lattices.
There are some things that are missing, but very clearly we won’t need to model individual ions and there is lots of other complexity that will not affect the outcome.