State’s politically appointed surgeon general claims vaccines can contaminate human DNA but experts say comment has no merit

An assertion by Florida’s politically appointed surgeon general that Covid-19 vaccines can contaminate human DNA has been dismissed as “scientific nonsense” by public health experts, who say he is putting lives at risk by wanting to block distribution.

“We’ve seen this pattern from Dr Ladapo that every few months he raises some new concern and it quickly gets debunked,” he told the Washington Post, referring to an erroneous claim in September that the latest release of Covid boosters had not been tested on humans.

“This idea of DNA fragments, it’s scientific nonsense. People who understand how these vaccines are made and administered understand that there is no risk here.”

Dr David Gorski, professor of surgery and oncology at Wayne State University and managing editor of Science-Based Medicine, which debunks misinformation in medicine, told the newspaper: “I’ve never seen a state health authority parrot anti-vaccine disinformation as a justification for stopping the use of a vaccine that has saved so many lives before.”

  • IHeartBadCode@kbin.social
    link
    fedilink
    arrow-up
    35
    ·
    10 months ago

    (continued)

    The preprint mentions this:

    Using fluorometry all vaccines exceed the guidelines for residual DNA set by FDA and WHO of 10 ng/dose by 188 – 509 fold

    Which is correct. The random DNA is considered a contaminant. But not because “oh no! It’s going to enter your DNA!!” but because of that first point I just mentioned.

    One, the DNA isn’t loaded up into the NLCs…until a random white blood cell sees it and says “this doesn’t belong here” and then nom-nom

    That contaminant will elicit an immune response to clean up the trash. That immune response can be your arm being super sore, you getting a bit feverish, and so on. You know, that shit they tell you about when you get the shot. 99.(a whole lot of nines thereafter)% of the trash will get picked up this way. But your immune response isn’t super big because it’s just trash clean up, your body knows the difference between that and infectious agent. The latter is what kicks in that tiredness and feeling really icky that comes with a vaccine, which that’s the mRNA’s doing.

    Which by the by the preprint mentions.

    However, qPCR residual DNA content in all vaccines were below these guidelines … with qPCR and SAEs warrant confirmation and further investigation

    This is because the preprint measured DNA via one method and got that 509 fold measure and then did it with a different way to measure and found < 10ng/does (that would be value the preprint is indicated in folds).

    And the thing is when these two values are so different, that is typically called BULLSHIT. Which is why on the way out they indicate “warrant confirmation and further investigation”. Basically, “I know my numbers are bullshit, but still… We should be on the watch!”

    And guess that’s the short version of this really long comment. The preprint admits, it’s fucking bullshit. And that Ladapo is resting on this bullshit for an argument is even higher piled bullshit.

    Okay that’s all I’m writing about this.

    • IHeartBadCode@kbin.social
      link
      fedilink
      arrow-up
      19
      ·
      10 months ago

      Okay I lied. This.

      In an exploratory analysis, we constructed dose response curves by plotting (Figure 8) the mass of DNA for spike (red) and plasmid ori (blue) found in Pfizer (upper panel) and Moderna (lower panel) vials against the SAE reporting ratio (SRR).

      SAE means Serious Adverse Effect and this comes from VAERS data. The same database that had someone turning into the incredible Hulk from a flu vaccine.

      Accordingly, for our exploratory dose response analysis we only used VAERS data originating outside the USA to reduce this confounding. Additionally, we have noted some discrepancies in data obtained through the downloaded version of the VAERS dataset

      I mean. Fuck these people and their bullshit. They are literally indicating that “yeah what we’re saying is bullshit” in technical terms but then get on Twitter and say “make a logical argument!” You basis for trend data on SAEs is shit. If qPCR in lab shows nothing (values underneath the threshold by the FDA), taking SAEs and saying “Oh well SOMEONE died according to the VAERS therefore there must be a multiple effect that if we take the base value we have found in lab and multiply by that, then it’s got to be a gazillion fold increase in DNA fragments!!”

      It’s all fucking bullshit logic and it’s a fucking preprint from October! No one is picking this up except the nuts because anyone with half a brain can see this is bullshit from start to finish. If you look at figure 7 and figure 8 in that preprint, we’re about to get algebra here, figure 7 shows a linear curve for both Pfizer and Moderna and Moderna is so clean, it goes off the graph when kept to the same scale which is why it has a red box around it. Then look at figure 8 where he adds in his SAEs, it’s a graph that just fucking flies upward geometrically.

      How anyone can sit there and present these two graphs and say “yeah I stand behind this extrapolation” is … I’ve run out of words, but it’s stupid! It’s literally this. What a fucking fraud. I cannot believe that this is the fucking world we are living in. This even being a thing people are citing is just quite literally the antithesis of science. And the ultimate conclusion of the preprint.

      Our exploratory analysis of the relationship between the residual DNA content and SAEs reported to VAERS is preliminary and limited in sample size but warrants confirmation by examining many more lots and vials

      NO. Absolutely NOT. Pulling an R2 out your ass and saying, “Oh this warrants us to get more free vials!” is some bullshit logic. To be clear, so the person tested in lab that concentration and found all the vials to be mostly clean (detectable DNA but under the FDA’s guidelines). And then took the Lot IDs of those and looked up how many SAE reports came up. Then took some Lot IDs that had a lot of SAEs and based on the information they had came up with a number of how much DNA would have been in those lots.

      So say you buy yogurt and find out 2 people got sick off the yogurt for Lot ID A and found that Lot ID A had 1% bad stuff in your lab. Where recall for the yogurt only happens at 5% bad stuff. Then you look up reports that Lot ID R had 23 people report being sick, so you go, “Oh well 23 is 11 and some change times worse, so Lot ID R must of had 12% bad stuff in it! I have no proof that Lot ID R had 12% bad stuff in it, but it must of have that much to get that many people sick!”

      THAT’S NOT LOGICAL!!

      Now granted the person indicates that they took some things into consideration and what not, but none of that matters. You’re just pulling numbers out of your ass. If you haven’t actually tested Lot ID R, you cannot say anything about it, especially using a database that people routinely lie to. And admitting that “oh there are some problems” doesn’t mean those problems disappear.

      I hate myself that I read that bullshit. I cannot believe this is the conversation. Florida is seriously fucked and it’s going to hurt people who don’t support this bullshit.

    • FuglyDuck@lemmy.world
      link
      fedilink
      English
      arrow-up
      5
      arrow-down
      3
      ·
      10 months ago

      So the reptilian shouldn’t be worried about his food supply going GMO?

      (Heh. Thanks for the thorough write up,)